Bioactive Small Molecules
Cayman Chemical Bnmetnb 5mg
A MEK1 and MEK2 inhibitor (IC50s = 1.8 and 0.92 nM, respectively); selective for MEK1/2 over RAF/MEK/ERK pathway kinases at 10 µM; reduces cell growth in HT-29, COLO 205, and LoVo cells (IC50s = 0.48, 0.52, and 2.2 nM, respectively); reduces tumor volume in a COLO 205 mouse xenograft model at 0.3 mg/kg
Cayman Chemical PIm-1 InhIbItr 2 1mg
A potent Pim-1 inhibitor (Ki = 91 nM) that targets the ATP-binding kinase hinge region
Cayman Chemical ANTIBODY PFK15 5mg
A selective inhibitor of PFKFB3 (IC50 = 207 nM); rapidly induces apoptosis in transformed cells, suppresses glucose uptake and growth of Lewis lung carcinomas in syngeneic mice, and yields antitumor effects in human xenograft models of cancer in athymic mice
Cayman Chemical ANTIBODY TCID 10mg
A tetrachloro indandione that acts as a potent inhibitor of UCH-L3 and demonstrates 125-fold selectivity over UCH-L1 (IC50s = 0.6 and 75 µM, respectively)
Cayman Chemical ANTIBODY ICG-001 1mg
A small molecule inhibitor of β-catenin/cyclic AMP responsive element binding protein (CREB) binding protein (CBP)-mediated transcription (IC50 = 3 µM); selectively induces apoptosis in transformed colon cells but not in normal cells and prevents the growth of colon carcinoma cells at 25 µM in vitro
Cayman Chemical ANTIBODY TobramycIn 500mg
An aminoglycoside antibiotic; binds to the 30S ribosomal subunit, inhibiting protein synthesis; active against a variety of Gram-positive and Gram-negative bacteria; reduces the number of CFUs in several mouse models of thigh infection
Cayman Chemical ANTIBODY PhloxIn B 10g
A red dye that can be used as an alternative to Gram staining; inhibits MRSA growth in vitro at 100 UG/ml; modulates channel activity of wild-type CFTR (Ki = 38 µM) and mutant delta F508 CFTR (Ki = 33 µM)
Cayman Chemical ANTIBODY 4EGI-1 5mg
An inhibitor of the initiation of translation that blocks the interaction of eIF4G with eIF4E (KD = 25 μM); prevents the expression of oncogenic proteins in mammalian cancer cells, leading to apoptosis; blocks translation in some viruses that do not require eIF4E or a cap structure for initiation
Medchemexpress LLC HY-10233 10mg Medchemexpress, Gaboxadol (hydrochloride) CAS:85118-33-8 Purity:>98%
Medchemexpress, HY-10233 10mg Gaboxadol (hydrochloride) CAS:85118-33-8 Gaboxadol hydrochloride (Lu 02-030 hydrochloride; THIP hydrochloride) is a potent agonist of the GABAA receptor and an antagonist of GABAC receptors (IC50=25 μM). Gaboxadol hydrochloride displays a partial agonist efficacy on subunit α1β2γ2 with an ED50 value of 143 µM, a full agonist efficacy at α5 subunit (ED50=28-129 µM) and a superagonist efficacy at α4β3δ (ED50=6 µM). Gaboxadol hydrochloride is a non-opioid analgesic and has hypnotic activities. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-111475 10mg Medchemexpress, Mitochondrial fusion promoter M1 CAS:219315-22-7 Purity:>98%
Medchemexpress, HY-111475 10mg Mitochondrial fusion promoter M1 CAS:219315-22-7 Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellular respiration. Mitochondrial fusion promoter M1 alleviates cardiac and brain damage in rats with cardiac ischemia/reperfusion injury. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-118297 10mg Medchemexpress, Ac4ManNAz CAS:361154-30-5 Purity:>98%
Medchemexpress, HY-118297 10mg Ac4ManNAz CAS:361154-30-5 Ac4ManNAz is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-109192 5mg Medchemexpress, Tolebrutinib CAS:1971920-73-6 Purity:>98%
Medchemexpress, HY-109192 5mg Tolebrutinib CAS:1971920-73-6 Tolebrutinib (SAR442168) is a potent, selective, orally active and brain-penetrant inhibitor of Bruton tyrosine kinase (BTK), with IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively. Tolebrutinib exhibits efficacy in central nervous system immunity. Tolebrutinib can be used for the research of multiple sclerosis (MS). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-112514 5mg Medchemexpress, 1,3,6,8-Tetrahydroxynaphthalene CAS:18512-30-6 Purity:>98%
Medchemexpress, HY-112514 5mg 1,3,6,8-Tetrahydroxynaphthalene CAS:18512-30-6 1,3,6,8-Tetrahydroxynaphthalene (T4HN) is an indispensable precursor to DHN (1,8-Dihydroxynaphthalene) melanin and is an unique symmetrical compound of polyketide origin. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-110228 1mg Medchemexpress, Metformin D6 (hydrochloride) CAS:1185166-01-1 Purity:>98%
Medchemexpress, HY-110228 1mg Metformin D6 (hydrochloride) CAS:1185166-01-1 Metformin D6 hydrochloride is a deuterium labeled Metformin hydrochloride. Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin hydrochloride triggers autophagy. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC HY-131335 5mg Medchemexpress, p38α inhibitor 2 CAS:1095003-80-7 Purity:>98%
Medchemexpress, HY-131335 5mg p38α inhibitor 2 CAS:1095003-80-7 p38α inhibitor 2 is a highly potent and selective p38α MAPK inhibitor, with a pIC50 of 9.6. p38α inhibitor 2 inhibits the hERG ion channel (IC50=27 μM) and shows a promising selectivity profile when tested in a panel of 51 other protein kinases (<30% inhibition at 10 μM concentration) and a panel of 141 other biological targets. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.